Freeze-drying equipment for large-scale laboratory use
نویسندگان
چکیده
منابع مشابه
Distribution of Vapor Pressure in the Vacuum Freeze-Drying Equipment
In the big vacuum freeze-drying equipment, the drying rate of materials is uneven at different positions. This phenomenon can be explained by the uneven distribution of vapor pressure in chamber during the freeze-drying process. In this paper, a mathematical model is developed to describe the vapor flow in the passageways either between material plates and in the channel between plate groups. T...
متن کاملUse of Stepscan DSC for Freeze-Drying Optimization
The production of many new drugs requires that the active material first be dissolved in water and then freeze-dried or lyophilized in order to generate a compound which is easily ingested and which also has a pleasing or pharmaceutically elegant appearance. The lyophilization process involves cooling an aqueous formulation to subambient temperatures and then pulling a vacuum to drive off the f...
متن کاملCirculating-Gas Freeze Drying
WAGMAN, JACK (U.S. Army Biological Laboratories, Frederick, Md.) AND EDWARD J. WENECK. Preservation of bacteria by circulating-gas freeze drying. Appl. Microbiol. 11:244-248. 1963.-Water-washed Serratia marcescens and Escherichia coli were freeze dried in a circulating-gas system at atmospheric pressure. This convective procedure resulted in a substantially higher survival of organisms than cou...
متن کاملFreeze-drying Process Development for Protein Pharmaceuticals
This chapter provides an overview of the impact of protein formulation variables on different stages of the protein freeze-drying process and offers guidance for selection of critical process parameters during protein freeze-drying cycle development, optimization, and scale-up. There is particular focus on practical considerations including large-scale process development, scale-up challenges, ...
متن کاملSperm freeze-drying; effects on sperm parameters
Today, sperm cryopreservation is a routine practice in infertility clinics. One of the alternative methods to preserve sperm is freeze-drying. This process consists of three steps. The first step is sample freezing, during which the solvent is separated from the solvent. Water forms ice crystals and the solute is placed between the ice crystals. Freezing may be done in a separate device or in a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1958
ISSN: 0306-3283
DOI: 10.1042/bj0680420